Backgrounds

Asthma
Carol Thompson

Bjrnsson E, Hjelm E, Janson C, Fridell E, Boman G. Serology of Chlamydia in relation to asthma and bronchial hyperresponsiveness. Scand J Infect Dis 1996;28(1):63-69. 122 ast & 75 gen pop ~age 33. P66 "Antibodies reactive with C tr (current, recent, or previous infection) were more common in subjects with antibodies to C pn than in those without (31 vs 13%, OR 3.0, CI 1.5-6.2).

Conversely, antibodies reactive with C pn were more common in subjects with antibodies to C tr than in those without (66 vs 39%). There was no significant difference in the prevalence of asthma this year, wheezing or BHR in subjects with C tr antibodies, with or without C pn antibodies."

 P67 CP current or recent & wheezing 6.7 (1.3-35.7); CT current or recent & ever asthma 7.7 (1.8- 32.2); asthma this year 13.9 (3.0-64.8); wheezing 5.3 (1.0-27.7); BHR 3.5 (0.9-13.5). CT previous also high ORs.

 P68 "Unexpectedly, the strongest connections were found between signs of C tr infections and reported asthma, symptoms of wheezing and breathlessness and BHR found. This relationship persisted after correction for atopy and smoking in a model of logistic regression.... Neonatal C tr pneumonia is, however, a rare event and, even in these cases, it is unlikely that antibody levels would persist for 20-40 years. Chlamydia trachomatis is not thought to be a respiratory pathogen in an adult population and, therefore, the pathophysiological explanation for the relationship found in our study is obscure.... An alternative to a direct causal relationship would be the possibility of a pulmonary infection by an as yet unidentified organism sharing common antigenic sites with C tr or even a chronic stimulation of antibody production after a venereal infection, implying a systemic mucosal abnormality in asthma."

Khan MA, Potter CW. The nPCR detection of Chlamydia pneumoniae and Chlamydia trachomatis in children hospitalized for bronchiolitis. J Infection 1996 Nov;33(3):173-175. 152 pts 0-25 mos. CP in only 1.3%, CT in 17.1%. P174 "Evidence exists that perinatally infected infants continue shedding of the organism from the nasopharynx and rectum for as long as 2.5 years, if untreated or inadequately treated. Thus, C trachomatis may be a constant source of morbidity in this age group." [And perhaps an uninvestigated cause of SIDS?]. RSV is the usual cause of bronchiolitis. 
 

Courtesy of Carol Thompson
Smokers' Rights Action Group
P.O. Box 259575
Madison, WI 53725-9575
Phone: 608-249-4568


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