Impaired Flush Response to Niacin Skin Patch Among Schizophrenia Patients and Their Nonpsychotic Relatives: The Effect of Genetic Loading
"We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia"
"Yet another feature of niacin is that it dilates blood vessels and creates a sensation of warmth, called a "niacin flush." This is often accompanied with a blushing of the skin. It is this "flush" or sensation of heat that indicates a temporary saturation of niacin, and that is our topic here."
Food For The Brain - Schizophrenia
"The use of ‘megadoses’ of niacin was first tried by Drs Humphrey Osmond and Abram Hoffer in 1951. So impressed were they with the results in acute schizophrenics that, in 1953, they ran the first double-blind therapeutic trials in the history of psychiatry. Their first two trials showed significant improvement giving at least 3gs (3,000mg) a day, compared to placebos. They also found that chronic schizophrenics, not first-time sufferers but long-term inpatients, showed little improvement. The results of six double blind controlled trials showed that the natural recovery rate was doubled. Later they found that even chronic patients, treated for several years with niacin in combination with other nutrients, often recovered"
http://www.foodforthebrain.org/content. ... ntent=1638