Coke Oven Emissions
Known to be a human carcinogen
First Listed in the Second Annual Report on Carcinogens (1981)Carcinogenicity
Coke oven emissions are known to be human carcinogens based on sufficient evidence of carcinogenicity in humans that indicates a causal relationship between exposure and cancer in humans.
Prior to 1950, there were numerous case reports that linked employment in coke production with cancers of the skin, bladder, and respiratory tract. Since then, several cohort studies conducted in the United States, United Kingdom, Japan, and Sweden have reported an increased risk of lung
cancer in humans exposed to coke oven emissions.
Smoking was accounted for in some of these studies and was not found to be a significant confounding factor."
A large cohort study of 59,000 steelworkers reported that lung cancer risk increased with increasing duration of exposure to coke-oven fumes or intensity of exposure. Several studies
of coke plant workers have reported an increased risk for kidney cancer.
An excess of cancer at other sites (prostate, large intestine, and pancreas) was reported in single studies (IARC 1984, 1987).
Coke oven emission samples applied weekly to the skin of mice for up to 52 weeks caused malignant skin tumors. These samples also showed tumor-initiating activity in mice. Several inhalation studies, using coal tar aerosols generated by samples collected from coke ovens, caused both benign and malignant lung tumors in rats and mice, and skin tumors in female mice.
Chemical analyses of coke oven emissions revealed the presence of numerous known carcinogens and potentially carcinogenic chemicals, including several polycyclic aromatic hydrocarbons (PAHs), nitrosamines, coal tar,arsenic compounds, and benzene. In addition to these carcinogens, coke oven emissions contain several agents known to enhance the effect of
chemical carcinogens, especially on the respiratory tract.
Exposure
The primary routes of potential human exposure to coke oven emissions are inhalation and dermal contact. Occupational exposure may occur during the production of coke from coal or while using coke to extract metals from their ores, to synthesize calcium carbide, or to manufacture graphite and electrodes.
Workers at coking plants and coal tar production plants, as well as the residents surrounding these plants, have a high risk of possible exposure to coke oven emissions.
http://ntp.niehs.nih.gov/ntp/roc/eleven ... 49coke.pdf
"In fact the first observations on an appreciable rise in the frequency of lung cancer were reported from the highly industrialized cities of densely populated Saxony during the first two decades of this century. Some years later it was found that high lung cancer rates existed for the population of the industrialized territory of the Ruhr valley, while they were below average for the agricultural region of the Main valley."
http://www.chestjournal.org/cgi/reprint/30/2/141